Octaplasma
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Octaplasma
Quick facts
- Dosing
12-15 mL Octaplasma/kg of body weight
- Administration
Infusion rate should not exceed 1 mL Octaplasma/kg of body weight/min
- Storage
48 months when stored at ≤ -18 °C
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Indications
Indications
- 1
Complex deficiencies of coagulation factors such as consumption coagulopathy e.g. disseminated intravascular coagulation (DIC) or coagulopathy due to severe hepatic failure, massive transfusion, or repeated large volume plasma exchange (especially in patients with impaired liver function).
- 2
Emergency substitution therapy in coagulation factor deficiencies, when situations, e.g. hemorrhage, do not allow a precise laboratory diagnosis, or when a specific coagulation factor concentrate is not available.
- 3
Rapid reversal of effects of oral anticoagulants when vitamin K is insufficient in emergency situations, or in patients with impaired liver function.
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Contraindications
Contraindications
- 1
Contraindicated in patients with IgA deficiency with documented antibodies against IgA as it may cause anaphylactic and anaphylactoid reactions.
- 2
Contraindicated in patients with severe deficiency of protein S as it may result in an increased risk of developing blood clots.
- 3
Contraindicated in patients who are hypersensitive to this drug or to any ingredient in the formulation, including any non-medicinal ingredient, or component of the container.
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Dosing
Dosing
- 1
The dosage depends upon the clinical situation and underlying disorder, but 12-15 mL Octaplasma/kg body weight is a generally accepted starting dose (this should increase the patient's plasma coagulation factor levels by approximately 25%).
- 2
An adequate hemostatic effect in minor and moderate hemorrhages or surgery is normally achieved after the infusion of 5-20 mL Octaplasma/kg body weight (this should increase the patient's plasma coagulation factor levels by approximately 10-33%).
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Preparation and handling
Preparation and Handling
Administration of Octaplasma must be based on ABO-blood group specificity
- In emergency cases
Octaplasma blood group AB can be regarded as universal plasma since it can be given to all patients.
- Administration
Octaplasma must be administered intravenously after thawing using an infusion set with a filter.
- Infusion rate
Should not exceed 0.020-0.025 mmol citrate/kg body weight/min, which equals to 1 mL Octaplasma/kg body weight/min.
For Blood Bank
- 1
Protect from light.
- 2
Thawed Octaplasma must not be refrozen.
- 3
After thawing, Octaplasma can be stored for up to 5 days at +2-8 °C or for up to 8 hours at room temperature (+20-25°C) before use.
- 4
Do not use solutions that are cloudy or have deposits.
for Clinicians
- 1
Octaplasma must not be mixed with other drugs as inactivation and precipitation may occur.
- 2
To avoid the possibility of clot formation, solutions containing calcium must not be administered by the same intravenous line as Octaplasma.
- 3
Due to the risk of activation/inactivation of Octaplasma, the concomitant administration of other blood products should be avoided as much as possible, except for emergency situations.
- 4
The product can be mixed with red blood cells and platelets.
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Safety
Safety measures
- 1
Risk of infectious agents with products made from human plasma.
- 2
Risk of allergic reaction.
- 3
Patients should be monitored for risk of thrombosis.
- 4
High dosages or infusion rates may induce hypervolaemia, pulmonary oedema and/or cardiac failure.
- 5
High infusion rates may cause cardiovascular effects as a result of citrate toxicity (fall in ionised calcium), especially in patients with liver function disorders.
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